Officials with the World Health Organization announced the group has temporarily paused its trial of an antimalarial drug touted by President Donald Trump as a possible treatment for COVID-19 due to concerns over its safety.
Director-General Tedros Adhanom Ghebreyesus of the WHO said Monday that the decision was made in light of an observational study published Friday in the medical journal The Lancet which found that coronavirus patients who were treated with hydroxychloroquine, chloroquine or a combination of either drug and an antibiotic were at a higher risk for death.
“The Executive Group of the Solidarity Trial, representing 10 of the participating countries, met on Saturday and has agreed to review a comprehensive analysis and critical appraisal of all evidence available globally,” Tedros said Monday.
“The review will consider data collected so far in the Solidarity Trial and, in particular, robust randomized available data, to adequately evaluate the potential benefits and harms from this drug."
Tedros said other coronavirus drug trials were continuing Monday.
“This concern relates to the use of hydroxychloroquine and chloroquine in COVID-19,” Tedros stressed. “I wish to reiterate that these drugs are accepted as generally safe for use in patients with autoimmune diseases or malaria.”
In the study published in The Lancet, researchers reviewed more than 96,000 COVID-19 cases in which patients were hospitalized between late December and mid-April. The data used for the study, which included 15,000 cases in which patients were treated with either hydroxychloroquine, chloroquine or a combination of the drugs with an antibiotic, came from 671 hospitals on six continents, researchers said.
"We were unable to confirm a benefit of hydroxychloroquine or chloroquine ... on in-hospital outcomes for COVID-19," researchers said in a summary of their findings. "Each of these drug regimens was associated with decreased in-hospital survival and an increased frequency of ventricular arrhythmias when used for treatment of COVID-19."
Trump has dismissed concerns around the safety of hydroxychloroquine and told reporters last week that he was taking a two-week regiment of the drug to protect himself against a coronavirus infection. The president said he was not advised to take the drug but that he instead requested it himself from the White House physician.
Scientists continue to race toward a vaccine for COVID-19, which White House officials have said is expected by the end of the year. Defense Secretary Mark Esper said Friday that he was confident a vaccine would be ready in the timeline given by officials.
"(The Department of Defense) has the expertise and the capacity of course, to get the manufacturing done and the logistics and I'm confident that we will deliver," he said during an appearance on NBC's "Today" show.
The United States has by far the most number of COVID-19 cases in the world with more than 1.6 million reported as of Monday afternoon, according to data compiled by Johns Hopkins University. At least 97,850 people have died of coronavirus infections nationwide, according to Johns Hopkins.